In vitro knowledge had been determined that characterize cytochrome P-450 (CYP-450) enzymes as possible substantial contributors to the first metabolism of many exogenous cannabinoids, and scientific pharmacogenetic info additional aid CYP2C9 as a substantial contributor to THC metabolism, as well as a pharmacokinetic interaction examine using ketoconazole with oromucosal cannabis https://hemalchem.com/product-category/am-series/