The recognised effects of such PTMs on ATXN2’s functionality and SCA2 pathogenesis stays constrained. In other polyQ ailments, numerous studies suggested that proteolytic cleavage of polyQ proteins could Enjoy a significant function in pathogenesis [36, 45]. Aligned using this strategy, the existence of the enriched forty two kDa fragment while in https://jacqueso777zku9.wikienlightenment.com/user