In more mature clients, That is critical to grasp as polypharmacy is widespread and can potentiate the chance of DDIs and ADRs. Thus, concurrent intake of CYP2D6 inhibitors or inducers could potentiate or block tramadol conversion into ODT and this could increase or lower efficacy/ADRs with the prescribed tramadol. https://hemalchem.com/product/o-dsmt/